土屋 尚之 / Tsuchiya, Naoyuki

医学医療系 教授 / Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

Response to: 'HLA-A∗ 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: Results from a genome wide association study' by Bluett et al
Association of MUC5B promoter polymorphism with interstitial lung disease in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population
Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene
Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population
HLA-A*31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: A multidrug hypersensitivity marker?
Transethnic meta-Analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis
Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population
MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease
難治性血管炎の新たな疾患感受性遺伝子を同定 ~ANCA関連血管炎発症リスクにTERT、DSP遺伝子多型が関連~
膠原病・自己免疫疾患のゲノム解析 | 土屋 尚之 | 筑波大学研究者カタログ
全身性強皮症の発症に関係する遺伝子多型を確認 ~転写因子FLI1のマイクロサテライト多型が発症に関連する~
活性酸素産生にかかわる遺伝子の多型が複数の膠原病発症リスクを高める~発症機序の解明や治療法開発につながると期待~
難治性血管炎における間質性肺疾患合併リスクと遺伝子多型との関連を同定 ~膠原病における未解決治療ニーズの解決に向けて~
免疫の基本原理を明らかにするこ とで疾患を克服する
難治性免疫疾患・アレルギー発症の分子機構解析と分子標的治療開発リサーチユニット
Overcome diseases by revealing the basic principles of immunity
患者さんのゲノム配列をもとに、最適な治療を提供する
ゲノム医科学リサーチユニット
Optimal Treatments Based on Patients’ Genome Sequences

 

論文 / Publication

  1. Advances in the genomics of ANCA-associated vasculitis—a view from East Asia Aya Kawasaki, Naoyuki Tsuchiya (2021)
  2. Association of TERT and DSP variants with microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis in a Japanese population: a genetic association study. Aya Kawasaki, Natsumi Namba, Ken-Ei Sada, Fumio Hirano, Shigeto Kobayashi, Kenji Nagasaka, Takahiko Sugihara, Nobuyuki Ono, Takashi Fujimoto, Makio Kusaoi, Naoto Tamura, Kunihiro Yamagata, Takayuki Sumida, Hiroshi Hashimoto, Shoichi Ozaki, Hirofumi Makino, Yoshihiro Arimura, Masayoshi Harigai, Naoyuki Tsuchiya 22 (1) 246 - 246 (2020)
  3. Association of a variant upstream of HLA-DRA with MPO-ANCA positive vasculitis Aya, Kawasaki, Ken-ei, Sada, Fumio, Hirano, Shigeto, Kobayashi, Kenji, Nagasaka, Takahiko, Sugihara, Nobuyuki, Ono, Takashi, Fujimoto, Makio, Kusaoi, Naoto, Tamura, Kunihiro, Yamagata, Takayuki, Sumida, Shoichi, Ozaki, Hiroshi, Hashimoto, Hirofumi, Makino, Yoshihiro, Arimura, Masayoshi, Harigai, Naoyuki, Tsuchiya Modern Rheumatology 30 (Supplement) S126 - S126 (2020)
  4. Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis Yamashita, Keita, Kawasaki, Aya, Matsushita, Takashi, Furukawa, Hiroshi, Kondo, Yuya, Okiyama, Naoko, Nagaoka, Shouhei, Shimada, Kota, Sugii, Shoji, Katayama, Masao, Hirohata, Shunsei, Okamoto, Akira, Chiba, Noriyuki, Suematsu, Eiichi, Setoguchi, Keigo, Migita, Kiyoshi, Sumida, Takayuki, Tohma, Shigeto, Hamaguchi, Yasuhito, Hasegawa, Minoru, Sato, Shinichi, Kawaguchi, Yasushi, Takehara, Kazuhiko, Tsuchiya, Naoyuki Rheumatology (Oxford, England) 59 (11) 3553 - 3562 (2020)
  5. Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population Nozomi Yokoyama, Aya Kawasaki, Takashi Matsushita, Hiroshi Furukawa, Yuya Kondo, Fumio Hirano, Ken ei Sada, Isao Matsumoto, Makio Kusaoi, Hirofumi Amano, Shouhei Nagaoka, Keigo Setoguchi, Tatsuo Nagai, Kota Shimada, Shoji Sugii, Atsushi Hashimoto, Toshihiro Matsui, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Shigeru Ohno, Masao Katayama, Kiyoshi Migita, Hajime Kono, Minoru Hasegawa, Shigeto Kobayashi, Hidehiro Yamada, Kenji Nagasaka, Takahiko Sugihara, Kunihiro Yamagata, Shoichi Ozaki, Naoto Tamura, Yoshinari Takasaki, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura, Masayoshi Harigai, Shinichi Sato, Takayuki Sumida, Shigeto Tohma, Kazuhiko Takehara, Naoyuki Tsuchiya 9 (1) (2019)
  6. Modulation of methotrexate-induced intestinal mucosal injury by dietary factors Higuchi, Takashi, Yoshimura, Mika, Oka, Shomi, Tanaka, Kosei, Naito, Takeshi, Yuhara, Satoshi, Warabi, Eiji, Mizuno, Seiya, Ono, Masao, Takahashi, Satoru, Tohma, Shigeto, Tsuchiya, Naoyuki, Furukawa, Hiroshi Hum Exp Toxicol 39 (4) 500 - 513 (2019)
  7. Association of HLA-DRB1 genotype with younger age onset and elder age onset rheumatoid arthritis in Japanese populations Oka, Shomi, Furukawa, Hiroshi, Shimada, Kota, Hashimoto, Atsushi, Komiya, Akiko, Tsunoda, Shinichiro, Saisho, Koichiro, Tsuchiya, Naoyuki, Katayama, Masao, Shinohara, Satoshi, Matsui, Toshihiro, Fukui, Naoshi, Sano, Hajime, Migita, Kiyoshi, Tohma, Shigeto Medicine 98 (48) (2019)
  8. Association of Functional (GA) n Microsatellite Polymorphism in the FLI1 Gene with Susceptibility to Human Systemic Sclerosis Kawasaki, Aya, Yamashita, Keita, Matsushita, Takashi, Furukawa, Hiroshi, Kondo, Yuya, Okiyama, Naoko, Nagaoka, Shouhei, Shimada, Kota, Sugii, Shoji, Katayama, Masao, Hirohata, Shunsei, Okamoto, Akira, Chiba, Noriyuki, Suematsu, Eiichi, Setoguchi, Keigo, Migita, Kiyoshi, Sumida, Takayuki, Tohma, Shigeto, Hasegawa, Minoru, Hamaguchi, Yasuhito, Sato, Shinichi, Kawaguchi, Yasushi, Takehara, Kazuhiko, Tsuchiya, Naoyuki ARTHRITIS & RHEUMATOLOGY 71 (S10) 3471 - 3474 (2019)
  9. Association of TERT and DSP Polymorphisms with Susceptibility to Myeloperoxidase- ANCA- Associated Vasculitis Kawasaki, Aya, Namba, Natsumi, Sada, Ken-ei, Hirano, Fumio, Kobayashi, Shigeto, Yamada, Hidehiro, Furukawa, Hiroshi, Nagasaka, Kenji, Sugihara, Takahiko, Suzuki, Aika, Yamagata, Kunihiro, Sumida, Takayuki, Tohma, Shigeto, Homma, Sakae, Ozaki, Shoichi, Hashimoto, Hiroshi, Makino, Hirofumi, Arimura, Yoshihiro, Harigai, Masayoshi, Tsuchiya, Naoyuki ARTHRITIS & RHEUMATOLOGY 71 (S10) 3474 - 3476 (2019)
  10. Genome- wide Association Study in a Japanese Population Revealed Novel Candidate Genes for Antineutrophil Cytoplasmic Antibody- associated Vasculitis Harigai, Masayoshi, Kawasaki, Aya, Tsuchiya, Naoyuki, Sada, Ken-Ei, Hirano, Fumio, Sugihara, Takahiko, Amano, Koichi, Yamagata, Kunihiro, Dobashi, Hiroaki, Nagasaka, Kenji, Atsumi, Tatsuya, Khor, Seik-Soon, Tokunaga, Katsushi, Ozaki, Shoichi, Matsuo, Seiichi, Arimura, Yoshihiro, Makino, Hirofumi ARTHRITIS & RHEUMATOLOGY 71 (S10) 3453 - 3455 (2019)
  11. 全身性エリテマトーデス-ゲノム解析から推測される発症関連分子経路- 土屋, 尚之, 横山 望 臨床免疫・アレルギー科 2019 363 - 371 (2019)
  12. HLA-DRB1 and FCGR2B: highlights of the first genome-wide association study of IgG4-related disease. Tsuchiya, Naoyuki, Kawasaki, Aya The Lancet Rheumatology 1 (1) e2 - e3 (2019)
  13. Human leukocyte antigen in Japanese patients with idiopathic inflammatory myopathy. Furukawa H, Oka S, Kawasaki A, Hidaka M, Shimada K, Kondo Y, Ihata A, Matsushita T, Matsumoto T, Hashimoto A, Matsumoto I, Komiya A, Kobayashi K, Osada A, Katayama M, Okamoto A, Setoguchi K, Kono H, Hamaguchi Y, Matsui T, Fukui N, Tamura H, Takehara K, Nagaoka S, Sugii S, Sumida T, Tsuchiya N, Tohma S Modern rheumatology 1 - 7 (2019)
  14. Human leukocyte antigen in Japanese patients with idiopathic inflammatory myopathy Furukawa, Hiroshi, Oka, Shomi, Kawasaki, Aya, Hidaka, Misaki, Shimada, Kota, Kondo, Yuya, Ihata, Atsushi, Matsushita, Takashi, Matsumoto, Takumi, Hashimoto, Atsushi, Matsumoto, Isao, Komiya, Akiko, Kobayashi, Kouji, Osada, Atsumu, Katayama, Masao, Okamoto, Akira, Setoguchi, Keigo, Kono, Hajime, Hamaguchi, Yasuhito, Matsui, Toshihiro, Fukui, Naoshi, Tamura, Hiroaki, Takehara, Kazuhiko, Nagaoka, Shouhei, Sugii, Shoji, Sumida, Takayuki, Tsuchiya, Naoyuki, Tohma, Shigeto Modern rheumatology Epub 1 - 7 (2019)
  15. Association study of MUC5B and TERT polymorphisms with interstitial lung disease in ANCA-associated vasculitis Kawasaki, Aya, Sada, Ken-ei, Hirano, Fumio, Kobayashi, Shigeto, Yamada, Hidehiro, Furukawa, Hiroshi, Nagasaka, Kenji, Sugihara, Takahiko, Suzuki, Aika, Yamagata, Kunihiro, Sumida, Takayuki, Tohma, Shigeto, Honma, Sakae, Ozaki, Shoichi, Hashimoto, Hiroshi, Makino, Hirofumi, Arimura, Yoshihiro, Harigai, Masayoshi, Tsuchiya, Naoyuki Modern Rheumatology 29 (Supplement) S122 - S123 (2019)
  16. Association of MUC5B promoter polymorphism with interstitial lung disease in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis Namba, Natsumi, Kawasaki, Aya, Sada, Ken-Ei, Hirano, Fumio, Kobayashi, Shigeto, Yamada, Hidehiro, Furukawa, Hiroshi, Shimada, Kota, Hashimoto, Atsushi, Matsui, Toshihiro, Nagasaka, Kenji, Sugihara, Takahiko, Suzuki, Aika, Yamagata, Kunihiro, Sumida, Takayuki, Tohma, Shigeto, Homma, Sakae, Ozaki, Shoichi, Hashimoto, Hiroshi, Makino, Hirofumi, Arimura, Yoshihiro, Harigai, Masayoshi, Tsuchiya, Naoyuki Annals of the rheumatic diseases 78 (8) 1144 (2019)
  17. Association of HLA Class II Alleles with Relapse and Interstitial Lung Disease in Myeloperoxidase (MPO) – ANCA Pseitive Vasculitis in a Japanese Population. Kawasaki, Aya, Sada, Ken-ei, Hirano, Fumio, Kobayashi, Shigeto, Yamada, Hidehiro, Furukawa, Hiroshi, Nagasaka, Kenji, Sugihara, Takahiko, Yamagata, Kunihiro, Sumida, Takayuki, Tohma, Shigeto, Ozaki, Shoichi, Hashimoto, Hiroshi, Makino, Hirofumi, Arimura, Yoshihiro, Tsuchiya, Naoyuki ARTHRITIS & RHEUMATOLOGY (2018)
  18. MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease Juge, P. -A, Lee, J. S, Ebstein, E, Furukawa, H, Dobrinskikh, E, Gazal, S, Kannengiesser, C, Ottaviani, S, Tsuchiya, N, Oka, S, Tohma, S, Rojas-Serrano, J, Gonzalez-Perez, M. -I, Mejia, M, Buendia-Roldan, I, Falfan-Valencia, R, Ambrocio-Ortiz, Enrique, Manali, E, Papiris, S. A, Karageorgas, T, Boumpas, D, Antoniou, K, Van Moorsel, C, van der Vis, J, de Man, Y, Grutters, J, Wang, Y, Borie, R, Wemeau-Stervinou, L, Wallaert, B, Flipo, R. -M, Nunes, H, Valeyre, D, Saidenberg, N, Boissier, Marie-Chris New England Journal of Medicine 379 (23) 2209 - 2219 (2018)
  19. MUC5B promoter Variant rs35705950 Is a Risk Factor for Rheumatoid Arthritis - Interstitial Lung Disease Juge, Pierre-Antoine, Lee, Joyce Sujin, Ebstein, Esther, Furukawa, Hiroshi, Dobrinskikh, Evgenia, Gazal, Steven, Kannengiesser, Caroline, Ottaviani, Sebastien, Oka, Shomi, Tohma, Shigeto, Tsuchiya, Naoyuki, Rojas-Serrano, Jorge, Gonzalez-Perez, Montserrat I, Mejia, Mayra, Buendia-Roldan, Ivette, Falfan-Valencia, Ramces, Ambrocio-Ortiz, Enrique, Manali, Effrosyni, Papiris, Spyros A, Karageorgas, Theofanis, Boumpas, Dimitrios, Antoniou, Katarina, van Moorsel, Coline H. M, van der Vis, Joanne, de Man, Yael A, Grutters ARTHRITIS & RHEUMATOLOGY 70 (9) (2018)
  20. Association of GTF2I Region Polymorphism with Systemic Lupus Erythematosus and Systemic Sclerosis, but Not with ANCA-Associated Vasculitis and Polymyositis/Dermatomyositis, in a Japanese Population Yokoyama, Nozomi, Kawasaki, Aya, Matsushita, Takashi, Furukawa, Hiroshi, Kondo, Yuya, Hirano, Fumio, Sada, Ken-ei, Matsumoto, Isao, Kusaoi, Makio, Amano, Hirofumi, Nagaoka, Shohei, Setoguchi, Keigo, Nagai, Tatsuo, Shimada, Kota, Sugii, Shouji, Hashimoto, Atsushi, Matsui, Toshihiro, Okamoto, Akira, Chiba, Noriyuki, Suematsu, Eiichi, Ohno, Shigeru, Katayama, Masao, Migita, Kiyoshi, Kono, Hajime, Hasegawa, Minoru, Kobayashi, Shigeto, Yamada, Hidehiro, Nagasaka, Kenji, Sugihara, Takahiko, Yamagata ARTHRITIS & RHEUMATOLOGY 70 (9) (2018)

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