島野 仁 / Shimano, Hitoshi

医学医療系 教授 / Professor at Faculty of Medicine

関連記事 / Related Articles in COTRE

In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: A potential role in adipocyte lipolysis
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
Transgenic mice overexpressing nuclear SREBP-1c in pancreatic β-cells
Lipolysis in the absence of hormone-sensitive lipase: Evidence for a common mechanism regulating distinct lipases
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia with Sterol Regulatory Element Binding Protein Involvement
Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice
SREBPs suppress IRS-2-mediated insulin signalling in the liver
Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: A meta-analysis
Polyunsaturated Fatty Acids Ameliorate Hepatic Steatosis in Obese Mice by SREBP-1 Suppression

 

論文 / Publication

  1. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition Nakagawa, Yoshimi, Wang, Yunong, Han, Song-Iee, Okuda, Kanako, Oishi, Asayo, Yagishita, Yuka, Kumagai, Kae, Ohno, Hiroshi, Osaki, Yoshinori, Mizunoe, Yuhei, Araki, Masaya, Murayama, Yuki, Iwasaki, Hitoshi, Konishi, Morichika, Itoh, Nobuyuki, Matsuzaka, Takashi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi Cellular and molecular gastroenterology and hepatology (2020)
  2. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model Shimizu, Yoshio, Tamura, Takafumi, Kemmochi, Akira, Owada, Yohei, Ozawa, Yusuke, Katsuji, Hisakura, Matsuzaka, Takashi, Shimano, Hitoshi, Nakano, Noriyuki, Sakashita, Shingo, Oda, Tatsuya, Ohkochi, Nobuhiro Journal of gastroenterology and hepatology Epub (2020)
  3. Balance capability and smell identification are associated with cognitive function in middle-aged persons with type 2 diabetes Suzuki, H, Midorikawa, M, Suzuki, Y, Sato, H, Nemoto, K, Yamauchi, K, Sugano, Y, Osaki, Y, Iwasaki, H, Sekiya, M, Yahagi, N, Hada, Y, Arai, T, Shimano, H DIABETOLOGIA 63 (SUPPL 1::1:SI) S455 - S456 (2020)
  4. Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia Yamashita, Shizuya, Masuda, Daisaku, Akishita, Masahiro, Arai, Hidenori, Asada, Yujiro, Dobashi, Kazushige, Egashira, Kensuke, Harada-Shiba, Mariko, Hirata, Kenichi, Ishibashi, Shun, Kajinami, Kouji, Kinoshita, Makoto, Kozaki, Koichi, Kuzuya, Masafumi, Ogura, Masatsune, Okamura, Tomonori, Sato, Kayoko, Shimano, Hitoshi, Tsukamoto, Kazuhisa, Yokode, Masayuki, Yokote, Koutaro, Yoshida, Masayuki Journal of atherosclerosis and thrombosis 27 (11) 1246 - 1254 (2020)
  5. Respiratory activity in psoriatic circulating T cells predicts the efficacy of apremilast Koguchi-Yoshioka, H, Watanabe, R, Matsumura, Y, Matsuzaka, T, Shimano, H, Fujimoto, M JOURNAL OF INVESTIGATIVE DERMATOLOGY 140 (7::S) S1 - S1 (2020)
  6. Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion Sekiya, Motohiro, Matsuda, Takaaki, Yamamoto, Yuki, Furuta, Yasuhisa, Ohyama, Mariko, Murayama, Yuki, Sugano, Yoko, Ohsaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Yatoh, Shigeru, Suzuki, Hiroaki, Shimano, Hitoshi BMC MEDICAL GENETICS 21 (1) (2020)
  7. A new perspective on type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease Matsuzaka, Takashi, Shimano, Hitoshi Journal of diabetes investigation 11 (3) 532 - 534 (2020)
  8. Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice Matsuzaka, Takashi, Kuba, Motoko, Koyasu, Saori, Yamamoto, Yuta, Motomura, Kaori, Arulmozhiraja, Sundaram, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Okajima, Yuka, Han, Song-Iee, Aita, Yuichi, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Ema, Masatsugu, Takahashi, Satoru, Tokiwa, Hiroaki, Shimano, Hitoshi Hepatology (Baltimore, Md.) 71 (5) 1609 - 1625 (2020)
  9. Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1 Ma, Yang, Sekiya, Motohiro, Kainoh, Kenta, Matsuda, Takaaki, Iwasaki, Hitoshi, Osaki, Yoshinori, Sugano, Yoko, Suzuki, Hiroaki, Takeuchi, Yoshinori, Miyamoto, Takafumi, Yahagi, Naoya, Nakagawa, Yoshimi, Matsuzaka, Takashi, Shimano, Hitoshi Biochemical and biophysical research communications 523 (2) 354 - 360 (2020)
  10. Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations Kawasaki, Mayu, Kambe, Akira, Yamamoto, Yuta, Arulmozhiraja, Sundaram, Ito, Sohei, Nakagawa, Yoshimi, Tokiwa, Hiroaki, Nakano, Shogo, Shimano, Hitoshi International journal of molecular sciences 21 (1) 361 (2020)

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知財 / Intellectual properties

  1. PCT/JP2006/300008 : 脂肪毒性の改善剤 島野, 仁
  2. 特願2004-115646 : 2型糖尿病モデルとしての非ヒトトランスジェニック動物 島野, 仁
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発行:筑波大学 URA研究戦略推進室・研究推進部