島野 仁 / Shimano, Hitoshi

医学医療系 教授 / Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology
In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: A potential role in adipocyte lipolysis
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
Transgenic mice overexpressing nuclear SREBP-1c in pancreatic β-cells
Lipolysis in the absence of hormone-sensitive lipase: Evidence for a common mechanism regulating distinct lipases
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia with Sterol Regulatory Element Binding Protein Involvement
Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice
SREBPs suppress IRS-2-mediated insulin signalling in the liver
Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: A meta-analysis

 

論文 / Publication

  1. Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan Tateishi, Ryosuke, Matsumura, Takeshi, Okanoue, Takeshi, Shima, Toshihide, Uchino, Koji, Fujiwara, Naoto, Senokuchi, Takafumi, Kon, Kazuyoshi, Sasako, Takayoshi, Taniai, Makiko, Kawaguchi, Takumi, Inoue, Hiroshi, Watada, Hirotaka, Kubota, Naoto, Shimano, Hitoshi, Kaneko, Shuichi, Hashimoto, Etsuko, Watanabe, Sumio, Shiota, Goshi, Ueki, Kohjiro, Kashiwabara, Kosuke, Matsuyama, Yutaka, Tanaka, Hideo, Kasuga, Masato, Araki, Eiichi, Koike, Kazuhiko Journal of gastroenterology 56 261 - 273 (2021)
  2. Elucidation of Apoa1 Gene Regulatory Mechanism Through Searching Causal Single-Nucleotide Variants Aita, Yuichi, Yahagi, Naoya, Takeuchi, Yoshinori, Ho, Man Hei, Saber, Zahra Mehrazad, Huyan, Yiren, Murayama, Yuki, Shikama, Akito, Masuda, Yukari, Izumida, Yoshihiko, Sekiya, Motohiro, Nakagawa, Yoshimi, Matsuzaka, Takashi, Kawakami, Yasushi, Shimano, Hitoshi CIRCULATION RESEARCH 127 (12) E280 - E281 (2020)
  3. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition Nakagawa, Yoshimi, Wang, Yunong, Han, Song-Iee, Okuda, Kanako, Oishi, Asayo, Yagishita, Yuka, Kumagai, Kae, Ohno, Hiroshi, Osaki, Yoshinori, Mizunoe, Yuhei, Araki, Masaya, Murayama, Yuki, Iwasaki, Hitoshi, Konishi, Morichika, Itoh, Nobuyuki, Matsuzaka, Takashi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi Cellular and molecular gastroenterology and hepatology (2020)
  4. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model Shimizu, Yoshio, Tamura, Takafumi, Kemmochi, Akira, Owada, Yohei, Ozawa, Yusuke, Katsuji, Hisakura, Matsuzaka, Takashi, Shimano, Hitoshi, Nakano, Noriyuki, Sakashita, Shingo, Oda, Tatsuya, Ohkochi, Nobuhiro Journal of gastroenterology and hepatology Epub (2020)
  5. Balance capability and smell identification are associated with cognitive function in middle-aged persons with type 2 diabetes Suzuki, H, Midorikawa, M, Suzuki, Y, Sato, H, Nemoto, K, Yamauchi, K, Sugano, Y, Osaki, Y, Iwasaki, H, Sekiya, M, Yahagi, N, Hada, Y, Arai, T, Shimano, H DIABETOLOGIA 63 (SUPPL 1::1:SI) S455 - S456 (2020)
  6. Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia Yamashita, Shizuya, Masuda, Daisaku, Akishita, Masahiro, Arai, Hidenori, Asada, Yujiro, Dobashi, Kazushige, Egashira, Kensuke, Harada-Shiba, Mariko, Hirata, Kenichi, Ishibashi, Shun, Kajinami, Kouji, Kinoshita, Makoto, Kozaki, Koichi, Kuzuya, Masafumi, Ogura, Masatsune, Okamura, Tomonori, Sato, Kayoko, Shimano, Hitoshi, Tsukamoto, Kazuhisa, Yokode, Masayuki, Yokote, Koutaro, Yoshida, Masayuki Journal of atherosclerosis and thrombosis 27 (11) 1246 - 1254 (2020)
  7. 肝臓の異常脂質蓄積【糖尿病:異所性脂肪に刮目せよ!-その意義と食事・運動・薬剤による最適解を考える-】 中川嘉, 島野, 仁 糖尿病プラクティス 37 (4) 426 - 432 (2020)
  8. Respiratory activity in psoriatic circulating T cells predicts the efficacy of apremilast Koguchi-Yoshioka, H, Watanabe, R, Matsumura, Y, Matsuzaka, T, Shimano, H, Fujimoto, M JOURNAL OF INVESTIGATIVE DERMATOLOGY 140 (7::S) S1 - S1 (2020)
  9. Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion Sekiya, Motohiro, Matsuda, Takaaki, Yamamoto, Yuki, Furuta, Yasuhisa, Ohyama, Mariko, Murayama, Yuki, Sugano, Yoko, Ohsaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Yatoh, Shigeru, Suzuki, Hiroaki, Shimano, Hitoshi BMC MEDICAL GENETICS 21 (1) (2020)
  10. A new perspective on type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease Matsuzaka, Takashi, Shimano, Hitoshi Journal of diabetes investigation 11 (3) 532 - 534 (2020)
  11. Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice Matsuzaka, Takashi, Kuba, Motoko, Koyasu, Saori, Yamamoto, Yuta, Motomura, Kaori, Arulmozhiraja, Sundaram, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Okajima, Yuka, Han, Song-Iee, Aita, Yuichi, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Ema, Masatsugu, Takahashi, Satoru, Tokiwa, Hiroaki, Shimano, Hitoshi Hepatology (Baltimore, Md.) 71 (5) 1609 - 1625 (2020)
  12. Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1 Ma, Yang, Sekiya, Motohiro, Kainoh, Kenta, Matsuda, Takaaki, Iwasaki, Hitoshi, Osaki, Yoshinori, Sugano, Yoko, Suzuki, Hiroaki, Takeuchi, Yoshinori, Miyamoto, Takafumi, Yahagi, Naoya, Nakagawa, Yoshimi, Matsuzaka, Takashi, Shimano, Hitoshi Biochemical and biophysical research communications 523 (2) 354 - 360 (2020)
  13. Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations Kawasaki, Mayu, Kambe, Akira, Yamamoto, Yuta, Arulmozhiraja, Sundaram, Ito, Sohei, Nakagawa, Yoshimi, Tokiwa, Hiroaki, Nakano, Shogo, Shimano, Hitoshi International journal of molecular sciences 21 (1) 361 (2020)
  14. Handgrip strength predicts new prediabetes cases among adults: A prospective cohort study Manda, Chrispin Mahala, Hokimoto, Takahiro, Okura, Tomohiro, Isoda, Hiroko, Shimano, Hitoshi, Wagatsuma, Yukiko Preventive medicine reports 17 (2020)
  15. 【線維症の病態と治療】代謝と線維化 中川 嘉, 島野, 仁 BIO Clinica 34 (12) 1197 - 1202 (2019)
  16. 【生体制御にかかわる多彩なリポクオリティ~基礎から病態まで~】リポクオリティと代謝疾患 松坂 賢, 島野, 仁 The Lipid 30 (4) 435 - 441 (2019)
  17. 【動脈硬化診療のすべて】(II章)動脈硬化を識る 成因 基礎研究 リポタンパク代謝・脂肪酸代謝 松田高明, 島野, 仁 日本医師会雑誌 148 (Suppl 2) S56 - S59 (2019)
  18. スタチンの薬理・薬効 大崎芳典, 島野, 仁 Current Therapy 37 (10) 937 - 942 (2019)
  19. 運動・トレーニングの外来指導(【「生活習慣病」診療の新潮: この10年で何が変わったか】ゼロ次予防・一次予防としての環境整備と生活指導) 鈴木康裕, 鈴木浩明, 島野, 仁 診断と治療 107 (9) 1123 - 1129 (2019)
  20. Rho-associated, coiled-coil-containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi Journal of diabetes investigation 10 (5) 1165 - 1167 (2019)

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※上記の論文リストは researchmapから取得した論文リストにDOIリンク等の情報を付加したものです。筑波大学研究者総覧(TRIOS)または researchmapの論文リストが更新されると後日反映されます。

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知財 / Intellectual properties

  1. PCT/JP2006/300008 : 脂肪毒性の改善剤 島野, 仁
  2. 特願2004-115646 : 2型糖尿病モデルとしての非ヒトトランスジェニック動物 島野, 仁
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発行:筑波大学 URA研究戦略推進室・研究推進部