島野 仁 / Shimano, Hitoshi

医学医療系 教授 / Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

The International Atherosclerosis Society Jean Charles Fruchart Prize 医学医療系 島野 仁
メタボリックシンドロームを制御する代謝産物センサー分子を発見
SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology
In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: A potential role in adipocyte lipolysis
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
Transgenic mice overexpressing nuclear SREBP-1c in pancreatic β-cells
Lipolysis in the absence of hormone-sensitive lipase: Evidence for a common mechanism regulating distinct lipases
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia with Sterol Regulatory Element Binding Protein Involvement
Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice
SREBPs suppress IRS-2-mediated insulin signalling in the liver
Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: A meta-analysis
Polyunsaturated Fatty Acids Ameliorate Hepatic Steatosis in Obese Mice by SREBP-1 Suppression
SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: Conceptual framework and therapeutic potential
肝臓のインスリン感受性を制御する脂質を発見
「乳児期のエピゲノム記憶が成人期の肥満に関連する仕組みを解明」 ~FGF21遺伝子のDNA脱メチル化が進むと、将来肥満になりにくい可能性〜
脂肪酸のバランスの異常が糖尿病を引き起こす
マクロファージがつくる不飽和脂肪酸が、炎症を収めるのに重要であることを発見 ―炎症の慢性化を抑え生活習慣病を防ぐ、新しい治療標的の可能性―(2016.12)
CKD49!? -慢性腎臓病と49地区医師会との戦い
基礎・社会・臨床医学の連携による健康長寿の実現リサーチユニット
‘CKD49’- Approaches to Treat Patients with Chronic Kidney Disease in Cooperation with Medical Associations in 49 districts
ナノ粒子・ナノ構造物で、副作用のない「理想のくすり」をつくりだす
筑波発ナノ粒子の包括的臨床応用リサーチユニット
Create “Ideal Drugs” without Adverse Effects Using Nanoparticles and Nanostructures
脂質の量から質へ 生活習慣病治療のパラダイムシフトをめざして
脂質エネルギー代謝リサーチユニット
From Quantitative to Qualitative Aspects of Lipids: Toward a Paradigm Shift in the Treatment of Lifestyle-Related Diseases
科学的根拠に基づく運動療法で病気を予防・治療する
分子スポトロジーリサーチユニット
Preventing and Treating Diseases with Evidence-based Exercise Therapy
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
HbA1c 5·7-6·4 and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): A longitudinal cohort study
Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: A meta-analysis
Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women A Meta-analysis
肺線維症の発症に脂質バランスが関与することを発見~肺疾患の予防・治療に向けた新しいメカニズムの解明~
#019:マウスがひらく新しい世界と共同研究の輪

 

論文 / Publication

  1. Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan Tateishi, Ryosuke, Matsumura, Takeshi, Okanoue, Takeshi, Shima, Toshihide, Uchino, Koji, Fujiwara, Naoto, Senokuchi, Takafumi, Kon, Kazuyoshi, Sasako, Takayoshi, Taniai, Makiko, Kawaguchi, Takumi, Inoue, Hiroshi, Watada, Hirotaka, Kubota, Naoto, Shimano, Hitoshi, Kaneko, Shuichi, Hashimoto, Etsuko, Watanabe, Sumio, Shiota, Goshi, Ueki, Kohjiro, Kashiwabara, Kosuke, Matsuyama, Yutaka, Tanaka, Hideo, Kasuga, Masato, Araki, Eiichi, Koike, Kazuhiko Journal of gastroenterology (2021)
  2. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition Nakagawa, Yoshimi, Wang, Yunong, Han, Song-Iee, Okuda, Kanako, Oishi, Asayo, Yagishita, Yuka, Kumagai, Kae, Ohno, Hiroshi, Osaki, Yoshinori, Mizunoe, Yuhei, Araki, Masaya, Murayama, Yuki, Iwasaki, Hitoshi, Konishi, Morichika, Itoh, Nobuyuki, Matsuzaka, Takashi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi Cellular and molecular gastroenterology and hepatology (2020)
  3. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model Shimizu, Yoshio, Tamura, Takafumi, Kemmochi, Akira, Owada, Yohei, Ozawa, Yusuke, Katsuji, Hisakura, Matsuzaka, Takashi, Shimano, Hitoshi, Nakano, Noriyuki, Sakashita, Shingo, Oda, Tatsuya, Ohkochi, Nobuhiro Journal of gastroenterology and hepatology Epub (2020)
  4. Balance capability and smell identification are associated with cognitive function in middle-aged persons with type 2 diabetes Suzuki, H, Midorikawa, M, Suzuki, Y, Sato, H, Nemoto, K, Yamauchi, K, Sugano, Y, Osaki, Y, Iwasaki, H, Sekiya, M, Yahagi, N, Hada, Y, Arai, T, Shimano, H DIABETOLOGIA 63 (SUPPL 1::1:SI) S455 - S456 (2020)
  5. Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia Yamashita, Shizuya, Masuda, Daisaku, Akishita, Masahiro, Arai, Hidenori, Asada, Yujiro, Dobashi, Kazushige, Egashira, Kensuke, Harada-Shiba, Mariko, Hirata, Kenichi, Ishibashi, Shun, Kajinami, Kouji, Kinoshita, Makoto, Kozaki, Koichi, Kuzuya, Masafumi, Ogura, Masatsune, Okamura, Tomonori, Sato, Kayoko, Shimano, Hitoshi, Tsukamoto, Kazuhisa, Yokode, Masayuki, Yokote, Koutaro, Yoshida, Masayuki Journal of atherosclerosis and thrombosis 27 (11) 1246 - 1254 (2020)
  6. 肝臓の異常脂質蓄積【糖尿病:異所性脂肪に刮目せよ!-その意義と食事・運動・薬剤による最適解を考える-】 中川嘉, 島野, 仁 糖尿病プラクティス 37 (4) 426 - 432 (2020)
  7. Respiratory activity in psoriatic circulating T cells predicts the efficacy of apremilast Koguchi-Yoshioka, H, Watanabe, R, Matsumura, Y, Matsuzaka, T, Shimano, H, Fujimoto, M JOURNAL OF INVESTIGATIVE DERMATOLOGY 140 (7::S) S1 - S1 (2020)
  8. Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion Sekiya, Motohiro, Matsuda, Takaaki, Yamamoto, Yuki, Furuta, Yasuhisa, Ohyama, Mariko, Murayama, Yuki, Sugano, Yoko, Ohsaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Yatoh, Shigeru, Suzuki, Hiroaki, Shimano, Hitoshi BMC MEDICAL GENETICS 21 (1) (2020)
  9. A new perspective on type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease Matsuzaka, Takashi, Shimano, Hitoshi Journal of diabetes investigation 11 (3) 532 - 534 (2020)
  10. Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice Matsuzaka, Takashi, Kuba, Motoko, Koyasu, Saori, Yamamoto, Yuta, Motomura, Kaori, Arulmozhiraja, Sundaram, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Okajima, Yuka, Han, Song-Iee, Aita, Yuichi, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Ema, Masatsugu, Takahashi, Satoru, Tokiwa, Hiroaki, Shimano, Hitoshi Hepatology (Baltimore, Md.) 71 (5) 1609 - 1625 (2020)

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知財 / Intellectual properties

  1. PCT/JP2006/300008 : 脂肪毒性の改善剤 島野, 仁
  2. 特願2004-115646 : 2型糖尿病モデルとしての非ヒトトランスジェニック動物 島野, 仁
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発行:筑波大学 URA研究戦略推進室・研究推進部