熊谷 嘉人 / Kumagai, Yoshito

医学医療系 教授 / Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

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Redox activity of airborne particulate matter at different sites in the Los Angeles Basin
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology
Control of protein function through oxidation and reduction of persulfidated states
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Adaptive response and protection against electrophilic stress | 熊谷嘉人| 筑波大学研究者カタログ
環境リスクから身を守る生体防御系には2つの経路が存在する 〜親電子物質の毒性を抑制する鍵分子を特定〜
シグナル伝達の異常に起因した疾患 を治療する創薬開発に向けた研究
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Research for drug discovery to treat diseases caused by abnormal cellular signaling
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility
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Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

 

論文 / Publication

  1. Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota Seki, Natsumi, Akiyama, Masahiro, Yamakawa, Hiroto, Hase, Koji, Kumagai, Yoshito, Kim, Yun-Gi The Journal of toxicological sciences 46 (2) 91 - 97 (2021)
  2. Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome Abiko, Yumi, Aoki, Hanako, Kumagai, Yoshito Toxicology and applied pharmacology 413 (2021)
  3. Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain Hiraoka, Hideki, Nomura, Ryosuke, Takasugi, Nobumasa, Akai, Ryoko, Iwawaki, Takao, Kumagai, Yoshito, Fujimura, Masatake, Uehara, Takashi Archives of toxicology (2021)
  4. Environmental pollutants and the immune response Suzuki, Takafumi, Hidaka, Takanori, Kumagai, Yoshito, Yamamoto, Masayuki Nature immunology 21 1486 - 1495 (2020)
  5. 親電子ストレスを制御するレドックスシグナル伝達と活性イオウ分子 神田, 洋紀, 熊谷, 嘉人 薬学雑誌 140 (9) 1119 - 1128 (2020)
  6. A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract Abiko, Yumi, Okada, Miyuki, Aoki, Hanako, Mizokawa, Mai, Kumagai, Yoshito Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2020)
  7. Transcriptional Induction of Cystathionine γ-Lyase, a Reactive Sulfur-Producing Enzyme, by Copper Diethyldithiocarbamate in Cultured Vascular Endothelial Cells Fujie, Tomoya, Takahashi, Akane, Takahashi, Musubu, Hara, Takato, Soyama, Asuka, Makino, Kosho, Takahashi, Hideyo, Yamamoto, Chika, Kumagai, Yoshito, Naka, Hiroshi, Kaji, Toshiyuki International journal of molecular sciences 21 (17) (2020)
  8. エクスポソーム―ヒトの健康に影響を与える環境曝露 熊谷,嘉人 実験医学増刊号 38 (10) 14 - 19 (2020)
  9. Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide Masahiro, Akiyama, Takamitsu, Unoki, Kumagai, Yoshito Fundamental Toxicological Sciences 7 (3) 161 - 166 (2020)
  10. Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain Akiyama, Masahiro, Unoki, Takamitsu, Yoshida, Eiko, Ding, Yunjie, Yamakawa, Hiroto, Shinkai, Yasuhiro, Ishii, Isao, Kumagai, Yoshito Toxicology letters 330 (15) 128 - 133 (2020)

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発行:筑波大学 URA研究戦略推進室・研究推進部