熊谷 嘉人 / Kumagai, Yoshito

医学医療系 教授 / Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

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Control of protein function through oxidation and reduction of persulfidated states
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Adaptive response and protection against electrophilic stress | 熊谷嘉人| 筑波大学研究者カタログ
環境リスクから身を守る生体防御系には2つの経路が存在する 〜親電子物質の毒性を抑制する鍵分子を特定〜
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Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

 

論文 / Publication

  1. Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor Abiko, Yumi, Taguchi, Keiko, Hisamori, Miwa, Hiyoshi-Arai, Kyoko, Luong, Nho Cong, Toriba, Akira, Kumagai, Yoshito Chemical research in toxicology (2022)
  2. Biotransformation of Morphinone and Its Glutathione Adduct Derived from Morphine by Anaerobic Gut Microbes in Guinea Pigs Kumagai, Yoshito Biological and Pharmaceutical Bulletin 45 (7) 968 - 971 (2022)
  3. Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome Akiyama, Masahiro, Shinkai, Yasuhiro, Yamakawa, Hiroto, Kim, Yun-Gi, Kumagai, Yoshito Chemosphere 299 134374 (2022)
  4. Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan Horai, Sawako, Abiko, Yumi, Unoki, Takamitsu, Shinkai, Yasuhiro, Akiyama, Masahiro, Nakata, Katsushi, Kunisue, Tatsuya, Kumagai, Yoshito Chemosphere 295 133833 (2022)
  5. A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones Luong, Nho Cong, Abiko, Yumi, Aoki, Hanako, Kumagai, Yoshito Biological & pharmaceutical bulletin 45 (6) 798 - 802 (2022)
  6. Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species Uchiyama, Jun, Akiyama, Masahiro, Hase, Koji, Kumagai, Yoshito, Kim, Yun-Gi Cell reports 38 (10) 110479 (2022)
  7. Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage Liu, Jun, Kasai, Shuya, Tatara, Yota, Yamazaki, Hiromi, Mimura, Junsei, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Sato, Tsubasa, Ozaki, Taku, Tanji, Kunikazu, Wakabayashi, Koichi, Maeda, Hayato, Mizukami, Hiroki, Shinkai, Yasuhiro, Kumagai, Yoshito, Tomita, Hirofumi, Itoh, Ken International Journal of Molecular Sciences 23 (6) 3201 (2022)
  8. Glyceraldehyde 3-phosphate dehydrogenase converts methylmercury to its sulfur adduct with lowered toxicity through sulfane sulfur atoms on Cys247 Abiko, Yumi, Eiko, Yoshida, Kumagai, Yoshito Fundamental Toxicological Sciences 9 (1) 1 - 5 (2022)
  9. Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain Unoki, Takamitsu, Akiyama, Masahiro, Shinkai, Yasuhiro, Kumagai, Yoshito, Fujimura, Masatake The Journal of toxicological sciences 47 (1) 31 - 37 (2022)
  10. Redox-dependent internalization of the purinergic P2Y receptor limits colitis progression Nishiyama, Kazuhiro, Nishimura, Akiyuki, Shimoda, Kakeru, Tanaka, Tomohiro, Kato, Yuri, Shibata, Takahiro, Tanaka, Hiroshi, Kurose, Hitoshi, Azuma, Yasu-Taka, Ihara, Hideshi, Kumagai, Yoshito, Akaike, Takaaki, Eaton, Philip, Uchida, Koji, Nishida, Motohiro Science signaling 15 (716) eabj0644 (2022)
  11. Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells Takahashi, Musubu, Kubota, Ayaka, Fujie, Tomoya, Shinkai, Yasuhiro, Kumagai, Yoshito, Nakano, Tsuyoshi, Hara, Takato, Yamamoto, Chika, Kaji, Toshiyuki BPB Reports 4 (6) 175 - 181 (2021)
  12. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways Takahashi, Musubu, Fujie, Tomoya, Nakano, Tsuyoshi, Hara, Takato, Shinkai, Yasuhiro, Takasawa, Ryoko, Hara, Yasushi, Kumagai, Yoshito, Yamamoto, Chika, Kaji, Toshiyuki International journal of molecular sciences 22 (21) 11762 (2021)
  13. The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice Abiko, Yumi, Katayama, Yusuke, Zhao, Wenyang, Horai, Sawako, Sakurai, Kenji, Kumagai, Yoshito SCIENTIFIC REPORTS 11 (1) 17598 (2021)
  14. Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation Wang, Chen, Okita, Yukari, Zheng, Ling, Shinkai, Yasuhiro, Manevich, Lev, Chin, Jas M, Kimura, Tomokazu, Suzuki, Hiroyuki, Kumagai, Yoshito, Kato, Mitsuyasu Cancer science 112 (10) 4187 - 4197 (2021)
  15. Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells Abiko, Yumi, Kurosawa, Kohki, Yamakawa, Hiroto, Kumagai, Yoshito The Journal of toxicological sciences 46 (4) 177 - 185 (2021)
  16. Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor Nakahara, Kengo, Hamada, Kyohei, Tsuchida, Tomoki, Takasugi, Nobumasa, Abiko, Yumi, Shien, Kazuhiko, Toyooka, Shinichi, Kumagai, Yoshito, Uehara, Takashi The Journal of biological chemistry 296 100524 (2021)
  17. Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts Abiko, Yumi, Katayama, Yusuke, Akiyama, Masahiro, Kumagai, Yoshito Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 150 112061 (2021)
  18. Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota Seki, Natsumi, Akiyama, Masahiro, Yamakawa, Hiroto, Hase, Koji, Kumagai, Yoshito, Kim, Yun-Gi The Journal of toxicological sciences 46 (2) 91 - 97 (2021)
  19. Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome Abiko, Yumi, Aoki, Hanako, Kumagai, Yoshito Toxicology and applied pharmacology 413 115392 (2021)
  20. Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain Hiraoka, Hideki, Nomura, Ryosuke, Takasugi, Nobumasa, Akai, Ryoko, Iwawaki, Takao, Kumagai, Yoshito, Fujimura, Masatake, Uehara, Takashi Archives of toxicology Epub (4) 1241 - 1250 (2021)

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発行:筑波大学 URA研究戦略推進室・研究推進部