高橋 智 / Takahashi, Satoru

医学医療系 教授 / Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need
O-linked glycosylation determines the nephritogenic potential of IgA rheumatoid factor
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation
Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs
Overexpression of GATA-3 protects against the development of hypersensitivity pneumonitis
Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes
Overexpression of Mafb in podocytes protects against diabetic nephropathy
MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development
C-Maf expression in angioimmunoblastic T-cell lymphoma
Indefinite Self-Renewal of ESCs through Myc/Max Transcriptional Complex-Independent Mechanisms
MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1
Transcription factors T-bet and GATA-3 regulate development of airway remodeling
Krüppel-like factor 5 Is Essential for Blastocyst Development and the Normal Self-Renewal of Mouse ESCs
Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
Forward-genetics analysis of sleep in randomly mutagenized mice
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
日本実験動物学会 安東・田嶋賞
ゲノム編集による遺伝子改変マウス作製 | 高橋 智 | 筑波大学研究者カタログ
慢性腎臓病の発症を抑えるしくみを解明 〜既存の白血病治療薬で腎障害悪化が抑制可能に〜
宇宙滞在による免疫機能低下の機構を解明 -無重力環境が引き起こす胸腺の萎縮と人工重力による軽減-
肝臓のインスリン感受性を制御する脂質を発見
国際宇宙ステーション・「きぼう」でのマウス飼育 により宇宙滞在が精子受精能力に及ぼす影響を解析 ―将来人類が宇宙へ活動領域を広げるにあたっての基礎的な知見の蓄積に―
ノックアウトマウス作製デザインが全自動でできるウェブツール”KOnezumi”の開発
マウスの動脈硬化病変部を体外から生きたまま観察する技術の開発 ~ 動脈硬化の特効薬開発に有用な画期的技術 〜
転写因子MAFB変異によるデュアン眼球後退症候群(DRS)と巣状糸球体硬化症(FSGS)合併の分子機序の解明
からだの死細胞を取り除く仕組みの解明
世界初、宇宙空間でμgから1 gを可変できる実験環境”MARS”が完成〜月・火星に向けた国際宇宙探査へのステップとなる、「きぼう」における可変人工重力環境の研究プラットフォーム ”MARS”-Multiple Artificial-gravity Research System-の確立
脳梗塞の炎症が収束するメカニズムを解明 ~白血病治療薬による脳梗塞の悪化阻止を確認~
酸化ストレスが糖尿病を引き起こすメカニズムを解明 ‐酸化ストレス防御機構による肥満および糖尿病の改善作用‐(2017.2)
精子幹細胞の分化と自己複製を両立する新たなメカニズムの発見 〜幹細胞は分化シグナルからどのように守られるのか〜(2017.2)
免疫の基本原理を明らかにするこ とで疾患を克服する
難治性免疫疾患・アレルギー発症の分子機構解析と分子標的治療開発リサーチユニット
Overcome diseases by revealing the basic principles of immunity
シグナル伝達の異常に起因した疾患 を治療する創薬開発に向けた研究
シグナル伝達と疾患リサーチユニット
Research for drug discovery to treat diseases caused by abnormal cellular signaling
内耳性難聴の治療を目指して
聴覚障害発症機序の解明に関する検討リサーチユニット
For the treatment of inner ear hearing loss
CKD49!? -慢性腎臓病と49地区医師会との戦い
基礎・社会・臨床医学の連携による健康長寿の実現リサーチユニット
‘CKD49’- Approaches to Treat Patients with Chronic Kidney Disease in Cooperation with Medical Associations in 49 districts
脂質の量から質へ 生活習慣病治療のパラダイムシフトをめざして
脂質エネルギー代謝リサーチユニット
From Quantitative to Qualitative Aspects of Lipids: Toward a Paradigm Shift in the Treatment of Lifestyle-Related Diseases
MafA is a key regulator of glucose-stimulated insulin secretion
Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
The transcriptional programme of antibody class switching involves the repressor Bach2
An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene
Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum
T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow
動脈硬化の進行を促進するたんぱく質を発見

 

論文 / Publication

  1. Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs Jeon, Hyojung, Asano, Keigo, Wakimoto, Arata, Kulathunga, Kaushalya, Tran, Mai Thi Nhu, Nakamura, Megumi, Yokomizo, Tomomasa, Hamada, Michito, Takahashi, Satoru Scientific reports 11 (1) 4374 (2021)
  2. Induction of mutant allele in neurons in late infancy increases sleep need Iwasaki, Kanako, Fujiyama, Tomoyuki, Nakata, Shinya, Park, Minjeong, Mioshi, Chika, Hotta-Hirashima, Noriko, Ikkyu, Aya, Kakizaki, Miyo, Sugiyama, Fumihiro, Mizuno, Seiya, Abe, Manabu, Sakimura, Kenji, Takahashi, Satoru, Funato, Hiromasa, Yanagisawa, Masashi The Journal of neuroscience : the official journal of the Society for Neuroscience Epub (2021)
  3. Mobilization efficiency is critically regulated by fat via marrow PPARδ Suzuki, Tomohide, Ishii, Shinichi, Shinohara, Masakazu, Kawano, Yuko, Wakahashi, Kanako, Kawano, Hiroki, Sada, Akiko, Minagawa, Kentaro, Hamada, Michito, Takahashi, Satoru, Furuyashiki, Tomoyuki, Tan, Nguan Soon, Matsui, Toshimitsu, Katayama, Yoshio Haematologica Epub (2021)
  4. Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs Jeon, Hyojung, Asano, Keigo, Wakimoto, Arata, Kulathunga, Kaushalya, Tran, Mai Thi Nhu, Nakamura, Megumi, Yokomizo, Tomomasa, Hamada, Michito, Takahashi, Satoru Scientific reports (2021)
  5. Effects of RORγt overexpression on the murine central nervous system Sasaki, Tetsuya, Nagata, Rei, Takahashi, Satoru, Takei, Yosuke Neuropsychopharmacology Reports 41 (1) 102 - 110 (2021)
  6. Study of mouse behavior in different gravity environments Shimomura, Michihiko, Yumoto, Akane, Ota-Murakami, Naoko, Kudo, Takashi, Shirakawa, Masaki, Takahashi, Satoru, Morita, Hironobu, Shiba, Dai Scientific reports 11 (1) 2665 (2021)
  7. Novel method for evaluating the health condition of mice in space through a video downlink Yumoto, Akane, Kokubo, Toshiaki, Izumi, Ryutaro, Shimomura, Michihiko, Funatsu, Osamu, Tada, Motoki N, Ota-Murakami, Naoko, Iino, Kayoko, Shirakawa, Masaki, Mizuno, Hiroyasu, Kudo, Takashi, Takahashi, Satoru, Suzuki, Takafumi, Uruno, Akira, Yamamoto, Masayuki, Shiba, Dai Experimental animals advpub (2021)
  8. FGF23 from erythroblasts promotes hematopoietic progenitor mobilization Ishii, Shinichi, Suzuki, Tomohide, Wakahashi, Kanako, Asada, Noboru, Kawano, Yuko, Kawano, Hiroki, Sada, Akiko, Minagawa, Kentaro, Nakamura, Yukio, Mizuno, Seiya, Takahashi, Satoru, Matsui, Toshimitsu, Katayama, Yoshio Blood Epub (2020)
  9. Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway Lee, Seung-Jun, Park, Jinah, Lee, Dong-Joon, Otsu, Keishi, Kim, Pyunggang, Mizuno, Seiya, Lee, Min-Jung, Kim, Hyun-Yi, Harada, Hidemitsu, Takahashi, Satoru, Kim, Seong-Jin, Jung, Han-Sung Cell death and differentiation Epub (2020)
  10. Suppressed ER-associated degradation by intraglomerular cross talk between mesangial cells and podocytes causes podocyte injury in diabetic kidney disease Fujimoto, Daisuke, Kuwabara, Takashige, Hata, Yusuke, Umemoto, Shuro, Kanki, Tomoko, Nishiguchi, Yoshihiko, Mizumoto, Teruhiko, Hayata, Manabu, Kakizoe, Yutaka, Izumi, Yuichiro, Takahashi, Satoru, Mukoyama, Masashi FASEB JOURNAL 34 (11) 15577 - 15590 (2020)
  11. Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like dermatitis through IL-6 Tanaka, Ryota, Ichimura, Yuki, Kubota, Noriko, Saito, Akimasa, Nakamura, Yoshiyuki, Ishitsuka, Yosuke, Watanabe, Rei, Fujisawa, Yasuhiro, Kanzaki, Mirei, Mizuno, Seiya, Takahashi, Satoru, Fujimoto, Manabu, Okiyama, Naoko COMMUNICATIONS BIOLOGY 3 (1) (2020)
  12. Nrf2 contributes to the weight gain of mice during space travel Suzuki, Takafumi, Uruno, Akira, Yumoto, Akane, Taguchi, Keiko, Suzuki, Mikiko, Harada, Nobuhiko, Ryoke, Rie, Naganuma, Eriko, Osanai, Nanae, Goto, Aya, Suda, Hiromi, Browne, Ryan, Otsuki, Akihito, Katsuoka, Fumiki, Zorzi, Michael, Yamazaki, Takahiro, Saigusa, Daisuke, Koshiba, Seizo, Nakamura, Takashi, Fukumoto, Satoshi, Ikehata, Hironobu, Nishikawa, Keizo, Suzuki, Norio, Hirano, Ikuo, Shimizu, Ritsuko, Oishi, Tetsuya, Motohashi, Hozumi, Tsubouchi, Hirona, Okada, Risa, Kudo, Takashi, Shimomura, Michihiko, Kensler, Thomas W, Mi Communications biology 3 (1) (2020)
  13. Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β Nakai, Ayaka, Fujiyama, Tomoyuki, Nagata, Nanae, Kashiwagi, Mitsuaki, Ikkyu, Aya, Takagi, Marina, Tatsuzawa, Chika, Tanaka, Kaeko, Kakizaki, Miyo, Kanuka, Mika, Kawano, Taizo, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Funato, Hiromasa, Sakurai, Takeshi, Yanagisawa, Masashi, Hayashi, Yu Genetics 216 (3) 753 - 764 (2020)
  14. An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition Deng, Zhaobin, Matsumoto, Yuka, Kuno, Akihiro, Ojima, Masami, Xiafukaiti, Gulibaikelamu, Takahashi, Satoru International journal of molecular sciences 21 (16) (2020)
  15. Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan Yamaguchi, Teruhide, Uchida, Eriko, Okada, Takashi, Ozawa, Keiya, Onodera, Masafumi, Kume, Akihiro, Shimada, Takashi, Takahashi, Satoru, Tani, Kenzaburo, Nasu, Yasutomo, Mashimo, Tomoji, Mizuguchi, Hiroyuki, Mitani, Kohnosuke, Maki, Kazushige HUMAN GENE THERAPY 31 (19-20) 1043 - 1053 (2020)
  16. Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis Morimoto, Kento, Numata, Koki, Daitoku, Yoko, Hamada, Yuko, Kobayashi, Keiko, Kato, Kanako, Suzuki, Hayate, Ayabe, Shinya, Yoshiki, Atsushi, Takahashi, Satoru, Murata, Kazuya, Mizuno, Seiya, Sugiyama, Fumihiro SCIENTIFIC REPORTS 10 (1) (2020)
  17. ANALYSIS OF A MOUSE MODEL FOR MCTO DUE TO THE MUTATION OF MAFB TRANSACTIVATION DOMAIN Usui, Toshiaki, Morito, Naoki, Tsunakawa, Yuki, Jeon, Hyojung, Hamada, Michito, Mizuno, Seiya, Takahashi, Satoru, Yamagata, Kunihiro NEPHROLOGY DIALYSIS TRANSPLANTATION 35 (3) 134 - 134 (2020)
  18. Gender difference in development of steatohepatitis in p62/Sqstm1 and Nrf2 double-knockout mice Watahiki, Takahisa, Okada, Kosuke, Warabi, Eiji, Nagaoka, Tsugumi, Suzuki, Hideo, Ishige, Kazunori, Yanagawa, Toru, Takahashi, Satoru, Mizokami, Yuji, Tokushige, Katsutoshi, Ariizumi, Shun-Ichi, Yamamoto, Masakazu, Shoda, Junichi Experimental animals 69 (4) 395 - 406 (2020)
  19. Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction Takato Honda, Yohko Takata, Yoan Cherasse, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa, Michael Lazarus, Yo Oishi 23 (6) 101240 - 101240 (2020)
  20. Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates Sato, Tempei, Kataoka, Kensuke, Ito, Yoshiaki, Yokoyama, Shigetoshi, Inui, Masafumi, Mori, Masaki, Takahashi, Satoru, Akita, Keiichi, Takada, Shuji, Ueno-Kudoh, Hiroe, Asahara, Hiroshi ELIFE 9 (2020)

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※上記の論文リストは researchmapから取得した論文リストにDOIリンク等の情報を付加したものです。筑波大学研究者総覧(TRIOS)または researchmapの論文リストが更新されると後日反映されます。

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知財 / Intellectual properties

  1. PCT/JP2018/042635 : 非ヒト動物及びその製造方法 濱田, 理人, 高橋智, 全孝静
  2. 得願2017-222215 : 非ヒト動物及びその製造方法 濱田, 理人, 高橋智, 全孝静
筑波大学研究ポータル University of Tsukuba research information Portal
COTRE(コトリ)|COmmunity of Tsukuba REsearchers

発行:筑波大学 URA研究戦略推進室・研究推進部