柳沢 正史 / Yanagisawa, Masashi

国際統合睡眠医科学研究機構 教授 / Professor, International Institute for Integrative Sleep Medicine

関連記事 / Related Articles in COTRE

高用量のオレキシン拮抗薬投与がナルコレプシー症状を誘発する
幼若期以降の神経細胞におけるタンパク質リン酸化酵素の遺伝子変異が眠気を増強する
木のぬくもりあふれる寝室で良い眠りを -木材・木質の内装や家具が多い寝室では不眠症の疑いが少ない-
睡眠ステージを自動的に判定する手法を開発 ~マウス4,200匹の睡眠時生体信号を学習・解析~
オレキシンによる体重制御の仕組みを解明 ~ 運動と摂食とエネルギー消費のバランス ~
人はなぜ眠る?最適な睡眠とは?「睡眠の謎」に最新の科学で迫る
眠気の「正体」にせまる新発見 睡眠の役割解明に道すじ
IIIS研究紹介アニメーション 国際統合睡眠医科学研究機構 筑波大学 Animation video of IIIS research - International Institute for Integrative Sleep Medicine, University of Tsukuba
寝ても寝ても眠いマウスの脳内メカニズム 〜単一遺伝子の単一アミノ酸が、1 日の睡眠時間と睡眠要求量・眠気を制御する~
Ptf1a が最上流遺伝子として、脳の男性化・女性化に働くことを発見 〜脳の性別を決定する新たなメカニズム〜
「眠気」の生化学的な実体に迫る ~睡眠要求を規定するリン酸化蛋白質群の同定~
捕食者の臭いを感知し、本能的な恐怖を惹起する新規臭いセンサーの発見 ~なぜ、マウスは捕食者の臭いを「学習」する必要がないのか~
麻薬性鎮痛薬による眠気に対する新しい戦略を提示 ~眠気の治療薬としてのオレキシン受容体作動薬の可能性~
マウスにおける正常妊娠と子癇前症での睡眠変化 ~母子の健康改善へ、あらたな道しるべ~
#001:「なぜ眠るのか」 その謎が解ける夜明け前の予感
ナルコレプシーの病因治療効果を確認 ~目覚めを制御する低分子医薬の新たな効果~
敗血症性ショックの治療に光 ~睡眠覚醒制御だけじゃないオレキシンの機能~(2017.01)
睡眠・覚醒制御の分子ネットワーク解明への道を拓く新規遺伝子の発見(2016.11.)
目覚めを制御する低分子医薬の発見 ~ 睡眠疾患の治療に大きな一歩 ~
地中海食薬の研究と創薬で、産業化と雇用創出を目指す
国際食薬・リサーチユニット
Aiming at industrialization and job creation by research and drug discovery of Mediterranean medicinal plants and food medicines
脂質の量から質へ 生活習慣病治療のパラダイムシフトをめざして
脂質エネルギー代謝リサーチユニット
From Quantitative to Qualitative Aspects of Lipids: Toward a Paradigm Shift in the Treatment of Lifestyle-Related Diseases
睡眠に関わる遺伝子特定 メカニズム解明に一歩
「なぜ眠るのか」その謎が解ける夜明け前の予感
不安を司る未知の副腎皮質ホルモン分泌制御機構を発見
覚醒時の経験が、その後の眠気に大きな影響を及ぼすことを立証

 

論文 / Publication

  1. Protein intake in inhabitants with regular exercise is associated with sleep quality: Results of the Shika study Suzuki, Fumihiko, Morita, Emi, Miyagi, Sakae, Tsujiguchi, Hiromasa, Hara, Akinori, Nguyen, Thao Thi Thu, Shimizu, Yukari, Hayashi, Koichiro, Suzuki, Keita, Kannon, Takayuki, Tajima, Atsushi, Matsumoto, Sumire, Ishihara, Asuka, Hori, Daisuke, Doki, Shotaro, Oi, Yuichi, Sasahara, Shinichiro, Satoh, Makoto, Matsuzaki, Ichiyo, Yanagisawa, Masashi, Ikaga, Toshiharu, Nakamura, Hiroyuki PloS one 16 (2) (2021)
  2. Induction of mutant allele in neurons in late infancy increases sleep need Iwasaki, Kanako, Fujiyama, Tomoyuki, Nakata, Shinya, Park, Minjeong, Mioshi, Chika, Hotta-Hirashima, Noriko, Ikkyu, Aya, Kakizaki, Miyo, Sugiyama, Fumihiro, Mizuno, Seiya, Abe, Manabu, Sakimura, Kenji, Takahashi, Satoru, Funato, Hiromasa, Yanagisawa, Masashi The Journal of neuroscience : the official journal of the Society for Neuroscience Epub (2021)
  3. Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial Zhang, Simeng, Takano, Jiro, Murayama, Norihito, Tominaga, Morie, Abe, Takashi, Park, Insung, Seol, Jaehoon, Ishihara, Asuka, Tanaka, Yoshiaki, Yajima, Katsuhiko, Suzuki, Yoko, Suzuki, Chihiro, Fukusumi, Shoji, Yanagisawa, Masashi, Kokubo, Toshio, Tokuyama, Kumpei Nutrients 12 (12) (2020)
  4. Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice Ogawa, Yukino, Miyoshi, Chika, Obana, Nozomu, Yajima, Kaho, Hotta-Hirashima, Noriko, Ikkyu, Aya, Kanno, Satomi, Soga, Tomoyoshi, Fukuda, Shinji, 柳沢, 正史 Scientific Reports 10 (1) 19554 (2020)
  5. Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β Nakai, Ayaka, Fujiyama, Tomoyuki, Nagata, Nanae, Kashiwagi, Mitsuaki, Ikkyu, Aya, Takagi, Marina, Tatsuzawa, Chika, Tanaka, Kaeko, Kakizaki, Miyo, Kanuka, Mika, Kawano, Taizo, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Funato, Hiromasa, Sakurai, Takeshi, Yanagisawa, Masashi, Hayashi, Yu Genetics 216 (3) 753 - 764 (2020)
  6. Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine Nagumo, Yasuyuki, Katoh, Koki, Iio, Keita, Saitoh, Tsuyoshi, Kutsumura, Noriki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Baba, Takeshi, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi Bioorganic & Medicinal Chemistry Letters 30 (17) (2020)
  7. Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine 柳沢,正史 Bioorganic & Medicinal Chemistry Letters 30 (17) 127360 - 127360 (2020)
  8. The role of endothelin B receptor in bone modelling during orthodontic tooth movement: a study on-ETB knockout rats Ibrahimi Disha, S, Furlani, B, Drevensek, G, Plut, A, Yanagisawa, M, Hudoklin, S, Prodan Žitnik, I, Marc, J, Drevensek, M Scientific reports 10 (1) (2020)
  9. Hypnotic effect of thalidomide is independent of teratigenic ubiquitin/proteasome pathway Yanagisawa,Masashi PNAS 117 (37) 23106 - 23112 (2020)
  10. A discrete neuronal circuit induces a hibernation-like state in rodents Takahashi, Tohru M, Sunagawa, Genshiro A, Soya, Shingo, Abe, Manabu, Sakurai, Katsuyasu, Ishikawa, Kiyomi, Yanagisawa, Masashi, Hama, Hiroshi, Hasegawa, Emi, Miyawaki, Atsushi, Sakimura, Kenji, Takahashi, Masayo, Sakurai, Takeshi Nature (2020)
  11. A discrete neuronal circuit induces a hibernation-like state in rodents Tohru M. Takahashi, Genshiro A. Sunagawa, Shingo Soya, Manabu Abe, Katsuyasu Sakurai, Kiyomi Ishikawa, Masashi Yanagisawa, Hiroshi Hama, Emi Hasegawa, Atsushi Miyawaki, Kenji Sakimura, Masayo Takahashi, Takeshi Sakurai (2020)
  12. Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction Honda, Takato, Takata, Yohko, Cherasse, Yoan, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Funato, Hiromasa, Yanagisawa, Masashi, Lazarus, Michael, Oishi, Yo iScience 23 (6) 101240 - 101240 (2020)
  13. Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction Takato Honda, Yohko Takata, Yoan Cherasse, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa, Michael Lazarus, Yo Oishi 23 (6) 101240 - 101240 (2020)
  14. A discrete neuronal circuit induces a hibernation-like state in rodents Takahashi, Tohru M, Sunagawa, Genshiro A, Soya, Shingo, Abe, Manabu, Sakurai, Katsuyasu, Ishikawa, Kiyomi, Yanagisawa, Masashi, Hama, Hiroshi, Hasegawa, Emi, Miyawaki, Atsushi, Sakimura, Kenji, Takahashi, Masayo, Sakurai, Takeshi Nature (2020)
  15. Structure of cortical network activity across natural wake and sleep states in mice Kaoru Ohyama, Takeshi Kanda, Takehiro Miyazaki, Natsuko Tsujino, Ryo Ishii, Yukiko Ishikawa, Hiroki Muramoto, Francois Grenier, Yuichi Makino, Thomas J. McHugh, Masashi Yanagisawa, Robert W. Greene, Kaspar E. Vogt 15 (5) e0233561 - e0233561 (2020)
  16. Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. Minjeong Park, Chika Miyoshi, Tomoyuki Fujiyama, Miyo Kakizaki, Aya Ikkyu, Takato Honda, Jinhwan Choi, Fuyuki Asano, Seiya Mizuno, Satoru Takahashi, Masashi Yanagisawa, Hiromasa Funato 10 (1) 8676 - 8676 (2020)
  17. Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation. Deependra Kumar, Iyo Koyanagi, Alvaro Carrier-Ruiz, Pablo Vergara, Sakthivel Srinivasan, Yuki Sugaya, Masatoshi Kasuya, Tzong-Shiue Yu, Kaspar E Vogt, Masafumi Muratani, Takaaki Ohnishi, Sima Singh, Catia M Teixeira, Yoan Chérasse, Toshie Naoi, Szu-Han Wang, Pimpimon Nondhalee, Boran A H Osman, Naoko Kaneko, Kazunobu Sawamoto, Steven G Kernie, Takeshi Sakurai, Thomas J McHugh, Masanobu Kano, Masashi Yanagisawa, Masanori Sakaguchi (2020)
  18. 長時間労働と睡眠時間・睡眠効率の関係:活動量計を用いた疫学研究 室井 慧, 森田えみ, 鈴木雅寛, 石原あすか, 松本すみ礼, 新井 陽, 池田 有, 堀, 大介, 道喜将太郎, 大井雄一, 笹原信一朗, 佐藤 誠, 柳沢正史, 松崎一葉 産業衛生学雑誌 62 (臨時増刊) 439 - 439 (2020)
  19. 労働者を対象としたクロノタイプ(朝型・昼型)と心理的ストレスの関連 新井 陽, 森田えみ, 鈴木雅寛, 石原あすか, 松本すみ礼, 室井 慧, 池田 有, 堀, 大介, 道喜将太郎, 大井雄一, 笹原信一朗, 佐藤 誠, 柳沢正史, 松崎一葉 産業衛生学雑誌 62 (臨時増刊) 394 - 394 (2020)
  20. Loss of Arc attenuates the behavioral and molecular responses for sleep homeostasis in mice Suzuki, Ayako, Yanagisawa, Masashi, Greene, Robert PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (19) 10547 - 10553 (2020)

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発行:筑波大学 URA研究戦略推進室・研究推進部