渋谷 和子 / Shibuya, Kazuko

医学医療系 准教授 / Associate Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

Exploring the Gut Fungi-Lung Allergy Axis
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions
Positional identification of an asthma susceptibility gene on human chromosome 5q33
Fcα/μ receptor mediates endocytosis of IgM-coated microbes
免疫難治疾患を対象とした免疫受容体分子標的療法の開発
がんが免疫の攻撃から逃がれる「もう一つの仕組み」の発見 〜がんの免疫療法に新たな可能性〜
免疫の基本原理を明らかにするこ とで疾患を克服する
難治性免疫疾患・アレルギー発症の分子機構解析と分子標的治療開発リサーチユニット
Overcome diseases by revealing the basic principles of immunity
シグナル伝達の異常に起因した疾患 を治療する創薬開発に向けた研究
シグナル伝達と疾患リサーチユニット
Research for drug discovery to treat diseases caused by abnormal cellular signaling
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo

 

論文 / Publication

  1. Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells. Okumura, Genki, Iguchi, Akiko, Murata, Rikito, Kanemaru, Yumi, Shibuya, Akira, Shibuya, Kazuko The Journal of Experimental Medicine 217 (4) (2020)
  2. A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease Y, Goshima, S, Nakaoka, K, Ohashi, H, Sakamaki, Shubuya, kazuko, Shibuya, Akira PLOS ONE 15 (2) (2020)
  3. Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation Miki, Haruka, Tahara-Hanaoka, Satoko, Almeida, Mariana Silva, Hitomi, Kaori, Shibagaki, Shohei, Kanemaru, Kazumasa, Lin, Yu-Hsien, Iwata, Kanako, Miyake, Shota, Shibayama, Shiro, Sumida, Takayuki, Shibuya, Kazuko, Shibuya, Akira Journal of immunology (Baltimore, Md. : 1950) (2020)
  4. Clec10a regulates mite-induced dermatitis. Kazumasa Kanemaru, Emiko Noguchi, Satoko Tahara-Hanaoka, Seiya Mizuno, Hiroaki Tateno, Kaori Denda-Nagai, Tatsuro Irimura, Hiroshi Matsuda, Fumihiro Sugiyama, Satoru Takahashi, Kazuko Shibuya, Akira Shibuya 4 (42) (2019)
  5. Expression and function of DNAM-1 on human B-lineage cells Nagayama-Hasegawa, Yuko, Honda, Shin-Ichiro, Shibuya, Akira, Shibuya, Kazuko Cytometry. Part B, Clinical cytometry Epub (2019)
  6. High expression of soluble CD155 in estrogen receptor-negative breast cancer Iguchi, Akiko, Okumura, Genki, Ichioka, Emika, Kiyomatsu, Hiroko, Ikeda, Tatsuhiko, Bando, Hiroko, Shibuya, Akira, Shibuya, Kazuko Breast Cancer Epub (1) 92 - 99 (2019)
  7. Exploring the Gut Fungi-Lung Allergy Axis Shibuya, Akira, K, Shibuya Cell Host Microbe 24 (6) 755 - 757 (2018)
  8. Elovl6 regulates mechanical damage–induced keratinocyte death and skin inflammation Y, Nakamura, T, Matsuzaka, S, Tahara-Hanaoka, K, Shibuya, H, Shimano, C, Nakahashi-Oda, A, Shibuya Cell Death and Diseases 9 (12) 1181 (2018)
  9. CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity Negishi, Naoko, Sato, Takehito, Yamashita-Kanemaru, Yumi, Shibuya, Kazuko, Uchida, Koichiro, Kametani, Yoshie, Yagita, Hideo, Kitaura, Jiro, Okumura, Ko, Habu, Sonoko ImmunoHorizons 2 (10) 338 - 348 (2018)
  10. Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation. Takenaka, Eri, Vo, Anh V, Yamashita-Kanemaru, Yumi, Shibuya, Akira, Shibuya, Kazuko Sci. Rep. 8 (1) 15180 (2018)
  11. Cutting edge: Identification of marginal reticular cells as phagocytes of apoptotic b cells in germinal centers Kazuki Sato, Shin-Ichiro Honda, Akira Shibuya, Kazuko Shibuya 200 (11) 3691 - 3696 (2018)
  12. TX99 Is a Neutralizing Monoclonal Antibody Against Mouse TIGIT Yuho Nakamura, Keisuke Naito, Yumi Yamashita-Kanemaru, Daisuke Komori, Rei Hirochika, Akira Shibuya, Kazuko Shibuya 37 (2) 105 - 109 (2018)
  13. Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers Sato, Kazuki, Honda, Shin-Ichiro, Shibuya, Akira, Shibuya, Kazuko Journal of immunology (Baltimore, Md. : 1950) (2018)
  14. A pro-inflammatory role of Fcα/μR on marginal zone B cells in sepsis Shibuya, Akira, Honda, Shin-Ichiro, Shibuya, Kazuko International immunology 29 (11) 519 - 524 (2017)
  15. アレルギー疾患におけるヘルパーT細胞の役割 渋谷, 和子 日本毒性学会学術年会 44 (2017)
  16. Expression of soluble CD155 in breast cancer Iguchi,Akiko, Akira,Shibuya, Kazuko,Shibuya 第75回日本癌学会学術総会プログラム (2016)
  17. CD155 (PVR/Necl5) mediates a costimulatory signal in CD4(+) T cells and regulates allergic inflammation Y. Yamashita-Kanemaru, G. Bernhardt, A. Shibuya, K. Shibuya 46 (1:SI) 997 - 997 (2016)
  18. Apoptotic epithelial cells control the abundance of regulatory T cells at barrier surfaces Nakahashi-Oda, C, Udayanga, K. G. S, Nakamura, Y, Nakazawa, Y, Totsuka, N, Miki, H, Iino, S, Tahara-Hanaoka, S, Honda, S, Shibuya, K, Shibuya, A NATURE IMMUNOLOGY 46 (1:SI) 776 - 777 (2016)
  19. 免疫応答におけるDNAM-1の役割 金丸 由美, 渋谷 和子, 渋谷 彰 臨床免疫・アレルギー科 66 (2) 177 - 183 (2016)
  20. Apoptotic epithelial cells control the abundance of T-reg cells at barrier surfaces Chigusa Nakahashi-Oda, Kankanam Gamage Sanath Udayanga, Yoshiyuki Nakamura, Yuta Nakazawa, Naoya Totsuka, Haruka Miki, Shuichi Iino, Satoko Tahara-Hanaoka, Shin-ichiro Honda, Kazuko Shibuya, Akira Shibuya 17 (4) 441 - + (2016)

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※上記の論文リストは researchmapから取得した論文リストにDOIリンク等の情報を付加したものです。筑波大学研究者総覧(TRIOS)または researchmapの論文リストが更新されると後日反映されます。

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知財 / Intellectual properties

  1. 特願2019-197223 : 免疫応答抑制剤 渋谷,和子
  2. PCT/JP2017/15767(先の国内特願2016-84170) : 制御性T細胞の活性化剤及びその使用 渋谷, 彰, 渋谷 和子, 阿部 史枝, 広近 玲, 奥村 元紀
  3. 特願2012-117542 : 同種間での移植心臓、移植血管、または移植腎臓の生着を維持するために用いられる薬剤 渋谷,彰, 渋谷,和子, 阿部,史枝
  4. 特願2015-012511 : 可溶型CD155タンパク質を用いた癌の検出方法 渋谷 彰, 渋谷 和子, 井口 研子
  5. 特願2016-84170 : 抗ヒトDNAM-1モノクローナル抗体及びその使用 渋谷 彰, 渋谷 和子, 阿部 史枝, 広近 玲, 奥村 元紀
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発行:筑波大学 URA研究戦略推進室・研究推進部