松坂 賢 / Matsuzaka, Takashi

医学医療系 教授 / Professor, Faculty of Medicine

関連記事 / Related Articles in COTRE

Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: A potential role in adipocyte lipolysis
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
SREBPs suppress IRS-2-mediated insulin signalling in the liver
Polyunsaturated Fatty Acids Ameliorate Hepatic Steatosis in Obese Mice by SREBP-1 Suppression
SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism
一般社団法人日本糖尿病学会2020年度リリー賞
肝臓のインスリン感受性を制御する脂質を発見
脂肪酸のバランスの異常が糖尿病を引き起こす
マクロファージがつくる不飽和脂肪酸が、炎症を収めるのに重要であることを発見 ―炎症の慢性化を抑え生活習慣病を防ぐ、新しい治療標的の可能性―(2016.12)
ナノ粒子・ナノ構造物で、副作用のない「理想のくすり」をつくりだす
筑波発ナノ粒子の包括的臨床応用リサーチユニット
Create “Ideal Drugs” without Adverse Effects Using Nanoparticles and Nanostructures
脂質の量から質へ 生活習慣病治療のパラダイムシフトをめざして
脂質エネルギー代謝リサーチユニット
From Quantitative to Qualitative Aspects of Lipids: Toward a Paradigm Shift in the Treatment of Lifestyle-Related Diseases
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
肺線維症の発症に脂質バランスが関与することを発見~肺疾患の予防・治療に向けた新しいメカニズムの解明~

 

論文 / Publication

  1. Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition Nakagawa, Yoshimi, Wang, Yunong, Han, Song-Iee, Okuda, Kanako, Oishi, Asayo, Yagishita, Yuka, Kumagai, Kae, Ohno, Hiroshi, Osaki, Yoshinori, Mizunoe, Yuhei, Araki, Masaya, Murayama, Yuki, Iwasaki, Hitoshi, Konishi, Morichika, Itoh, Nobuyuki, Matsuzaka, Takashi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi Cellular and molecular gastroenterology and hepatology (2020)
  2. Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model Shimizu, Yoshio, Tamura, Takafumi, Kemmochi, Akira, Owada, Yohei, Ozawa, Yusuke, Katsuji, Hisakura, Matsuzaka, Takashi, Shimano, Hitoshi, Nakano, Noriyuki, Sakashita, Shingo, Oda, Tatsuya, Ohkochi, Nobuhiro Journal of gastroenterology and hepatology Epub (2020)
  3. Respiratory activity in psoriatic circulating T cells predicts the efficacy of apremilast Koguchi-Yoshioka, H, Watanabe, R, Matsumura, Y, Matsuzaka, T, Shimano, H, Fujimoto, M JOURNAL OF INVESTIGATIVE DERMATOLOGY 140 (7::S) S1 - S1 (2020)
  4. A new perspective on type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease Matsuzaka, Takashi, Shimano, Hitoshi Journal of diabetes investigation 11 (3) 532 - 534 (2020)
  5. Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice Matsuzaka, Takashi, Kuba, Motoko, Koyasu, Saori, Yamamoto, Yuta, Motomura, Kaori, Arulmozhiraja, Sundaram, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Okajima, Yuka, Han, Song-Iee, Aita, Yuichi, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Ema, Masatsugu, Takahashi, Satoru, Tokiwa, Hiroaki, Shimano, Hitoshi Hepatology (Baltimore, Md.) 71 (5) 1609 - 1625 (2020)
  6. Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1 Ma, Yang, Sekiya, Motohiro, Kainoh, Kenta, Matsuda, Takaaki, Iwasaki, Hitoshi, Osaki, Yoshinori, Sugano, Yoko, Suzuki, Hiroaki, Takeuchi, Yoshinori, Miyamoto, Takafumi, Yahagi, Naoya, Nakagawa, Yoshimi, Matsuzaka, Takashi, Shimano, Hitoshi Biochemical and biophysical research communications 523 (2) 354 - 360 (2020)
  7. 【生体制御にかかわる多彩なリポクオリティ~基礎から病態まで~】リポクオリティと代謝疾患 松坂 賢, 島野, 仁 The Lipid 30 (4) 435 - 441 (2019)
  8. Rho-associated, coiled-coil-containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi Journal of diabetes investigation 10 (5) 1165 - 1167 (2019)
  9. 脂肪酸伸長酵素ELOVL6による肝臓インスリン感受性制御機構の解析 松坂 賢, 林, 昭夫, 島野, 仁 脂質生化学研究 61 183 - 185 (2019)
  10. 肪酸クオリティと疾患制御 脂肪酸の"質"を制御する 脂肪酸伸長酵素とその関連疾患 本村香織, 松坂 賢, 島野, 仁 医学のあゆみ 269 (13) 976 - 982 (2019)

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発行:筑波大学 URA研究戦略推進室・研究推進部