深水 昭吉 / Fukamizu, Akiyoshi

生存ダイナミクス研究センター 教授 / Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)

関連記事 / Related Articles in COTRE

Bowel disease drug shows unexpected mechanism
Deficiency of cardiac natriuretic peptide signaling promotes peripartum cardiomyopathy-like remodeling in the mouse heart
Angiotensinogen gene-activating elements regulate blood pressure in the brain
Physiological function of the angiotensin AT1a receptor in bone remodeling
Phosphatidylinositol 3-Kinase/Akt Regulates Angiotensin II-Induced Inhibition of Apoptosis in Microvascular Endothelial Cells by Governing Survivin Expression and Suppression of Caspase-3 Activity
Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart
Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling
Activation of renin-angiotensin system induces osteoporosis independently of hypertension
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
SREBPs suppress IRS-2-mediated insulin signalling in the liver
炎症性腸疾患の分子機構の解明と治療戦略の創出
ヒスタミン受容体アゴニストが心腎連関障害を改善する – 心腎不全モデルマウスの遺伝情報解析による抗炎症作用の同定 –
受容体間の機能的相互作用による血管収縮機構を解明
新発見! ADHD治療につながるタンパク質? ~2つの機能を持つPRMT8~
若齢期の拡張型心筋症の要因を解明 ~アルギニンメチル化酵素PRMT1欠損が心臓での遺伝子転写に異常をもたらす~
炎症性腸疾患の治療に有用な新規抗炎症メカニズムを解明 ~病変部位への白血球浸潤を抑制する低分子化合物~
#009 栄養・出産・寿命 遺伝子に刻まれた「普通の営み」の暗号を解く
中枢神経系の発生や機能維持に重要な仕組みの一端を解明 ~オリゴデンドロサイトの分化・成熟へのタンパク質メチル化の効果~(2016.02)
「お化け」遺伝子を呼び出す「こっくりさん」タンパク質の発見 ~昆虫のステロイドホルモン生合成に関わる新知見~
生命の源「海」を見つめ、 「ヒト」をより深く理解する
海洋生物学リサーチユニット
Investigate the source of life “sea” to deeply understand “human beings”
脂質の量から質へ 生活習慣病治療のパラダイムシフトをめざして
脂質エネルギー代謝リサーチユニット
From Quantitative to Qualitative Aspects of Lipids: Toward a Paradigm Shift in the Treatment of Lifestyle-Related Diseases
Identification and functional analysis of endothelial tip cell-enriched genes
Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen
Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
Silent information regulator 2 potentiates Foxo 1-mediated transcription through its deacetylase activity
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Impaired blood-brain barrier function in angiotensinogen-deficient mice
Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt
Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
栄養・出産・寿命 遺伝子に刻まれた「普通の営み」の暗号を解く

 

論文 / Publication

  1. Transcriptomic Evaluation of Pulmonary Fibrosis-Related Genes: Utilization of Transgenic Mice with Modifying p38 Signal in the Lungs Matsuda, Shuichi, Kim, Jun-Dal, Sugiyama, Fumihiro, Matsuo, Yuji, Ishida, Junji, Murata, Kazuya, Nakamura, Kanako, Namiki, Kana, Sudo, Tatsuhiko, Kuwaki, Tomoyuki, Hatano, Masahiko, Tatsumi, Koichiro, Fukamizu, Akiyoshi, Kasuya, Yoshitoshi International journal of molecular sciences 21 (18) (2020)
  2. Transcriptomic changes involved in the dedifferentiation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis Suzuki, Kenichi, Kim, Jun-Dal, Ugai, Keita, Matsuda, Shuichi, Mikami, Hideki, Yoshioka, Kento, Ikari, Jun, Hatano, Masahiko, Fukamizu, Akiyoshi, Tatsumi, Koichiro, Kasuya, Yoshitoshi Molecular medicine reports 22 (2) 1518 - 1526 (2020)
  3. Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B Fujimura, Akiko, Hayashi, Yuki, Kato, Kazashi, Kogure, Yuichiro, Kameyama, Mutsuro, Shimamoto, Haruka, Daitoku, Hiroaki, Fukamizu, Akiyoshi, Hirota, Toru, Kimura, Keiji Nucleic acids research 48 (12) 6583 - 6596 (2020)
  4. Region-specific upregulation of HNK-1 glycan in the PRMT1-deficient brain Hashimoto, Misuzu, Hirata, Tetsuya, Yonekawa, Chizuko, Takeichi, Kaho, Fukamizu, Akiyoshi, Nakagawa, Tsutomu, Kizuka, Yasuhiko Biochimica et biophysica acta. General subjects 1864 (3) (2020)
  5. Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart. Kentaro Otani, Takeshi Tokudome, Chizuko A Kamiya, Yuanjie Mao, Hirohito Nishimura, Takeshi Hasegawa, Yuji Arai, Mari Kaneko, Go Shioi, Junji Ishida, Akiyoshi Fukamizu, Tsukasa Osaki, Chiaki Nagai-Okatani, Naoto Minamino, Takuya Ensho, Jun Hino, Shunsuke Murata, Misa Takegami, Kunihiro Nishimura, Ichiro Kishimoto, Mikiya Miyazato, Mariko Harada-Shiba, Jun Yoshimatsu, Kazuwa Nakao, Tomoaki Ikeda, Kenji Kangawa 141 (7) 571 - 588 (2020)
  6. Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming. Kazuyuki Noguchi, Junji Ishida, Jun-Dal Kim, Naoto Muromachi, Koichiro Kako, Hayase Mizukami, Weizhe Lu, Tomohiro Ishimaru, Shohei Kawasaki, Shuzo Kaneko, Joichi Usui, Hiroshi Ohtsu, Kunihiro Yamagata, Akiyoshi Fukamizu (2020)
  7. Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming. Kazuyuki Noguchi, Junji Ishida, Jun-Dal Kim, Naoto Muromachi, Koichiro Kako, Hayase Mizukami, Weizhe Lu, Tomohiro Ishimaru, Shohei Kawasaki, Shuzo Kaneko, Joichi Usui, Hiroshi Ohtsu, Kunihiro Yamagata, Akiyoshi Fukamizu 117 (6) 3150 - 3156 (2020)
  8. Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction Nagano, Katsumasa, Kwon, Chulwon, Ishida, Junji, Hashimoto, Tatsuo, Jun-Dal, Kim, Kishikawa, Nana, Murao, Mei, Kimura, Kenjiro, Kasuya, Yoshitoshi, Kimura, Sadao, Chen, Yi-Ching, Tsuchimochi, Hirotsugu, Shirai, Mikiyasu, Pearson, James T, Fukamizu, Akiyoshi Journal of biochemistry 166 (5) 383 - 392 (2019)
  9. Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart. Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K Circulation (2019)
  10. Cables2 Is a Novel Smad2-Regulatory Factor Essential for Early Embryonic Development in Mice Tra Thi Huong Dinh, Hiroyoshi Iseki, Seiya Mizuno, Saori Iijima-Mizuno, Yoko Tanimoto, Yoko Daitoku, Kanako Kato, Yuko Hamada, Ammar Shaker, Hamed Hasan, Hayate Suzuki, Kazuya Murata, Masafumi Muratani, Masatsugu Ema, Jun-Dal Kim, Junji Ishida, Akiyoshi Fukamizu, Mitsuyasu Kato, Satoru Takahashi, Ken-ichi Yagami, Valerie Wilson, Ruth M Arkell, Fumihiro Sugiyama (2019)

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※上記の論文リストは researchmapから取得した論文リストにDOIリンク等の情報を付加したものです。筑波大学研究者総覧(TRIOS)または researchmapの論文リストが更新されると後日反映されます。

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知財 / Intellectual properties

  1. 特願2014-090001 : 化合物の抗炎症効果または免疫抑制効果を予測する方法 深水昭吉, 金俊逹, 大黒理勝
  2. 015-12850 : 細胞を分離・解析する方法 深水昭吉, 金俊達, 萩原昌彦, 和田幸周
  3. 2015-12851 : 活性化白血球の除去方法 深水昭吉, 金俊達, 萩原昌彦, 和田幸周
  4. 2014-190001 : 化合物の抗炎症効果または免疫抑制効果を予測する方法 深水昭吉, 金俊達, 大黒, 理勝
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発行:筑波大学 URA研究戦略推進室・研究推進部